Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia

Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by β-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse. HAMP expression is activated by iron through the...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Nai, Antonella, Pagani, Alessia, Mandelli, Giacomo, Lidonnici, Maria Rosa, Silvestri, Laura, Ferrari, Giuliana, Camaschella, Clara
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2012
Предметы:
Red Cells, Iron, and Erythropoiesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426375/
https://ncbi.nlm.nih.gov/pubmed/22490684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401885
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы