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Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia
Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by β-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse. HAMP expression is activated by iron through the...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426375/ https://ncbi.nlm.nih.gov/pubmed/22490684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401885 |
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