Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia

Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by β-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse. HAMP expression is activated by iron through the...

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Bibliographic Details
Main Authors: Nai, Antonella, Pagani, Alessia, Mandelli, Giacomo, Lidonnici, Maria Rosa, Silvestri, Laura, Ferrari, Giuliana, Camaschella, Clara
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426375/
https://ncbi.nlm.nih.gov/pubmed/22490684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401885
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