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B-1 cells in the bone marrow are a significant source of natural IgM

Natural IgM antibodies secreted in the absence of antigenic challenge are important contributors to antimicrobial immunity and tissue homeostasis. Early studies had identified bone marrow and, to a lesser extent the spleen, as main tissue sources of this spontaneously secreted IgM. However, the resp...

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Detalhes bibliográficos
Main Authors: Choi, Youn Soo, Dieter, Jacquelyn A., Rothaeusler, Kristina, Luo, Zheng, Baumgarth, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426357/
https://ncbi.nlm.nih.gov/pubmed/22009734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141890
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