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Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction
It is unclear why selective deficiency in secreted (s)IgM causes antibody-mediated autoimmunity. We demonstrate that sIgM is required for normal B cell development and selection. The CD5+ B cells that were previously shown to accumulate in body cavities of sIgM−/− mice are not B-1a cells, but CD19(i...
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| Published in: | J Immunol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324358/ https://ncbi.nlm.nih.gov/pubmed/25595791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401880 |
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