Toxicological and Pharmacokinetic Properties of Chemically Modified siRNAs Targeting p53 RNA Following Intravenous Administration

We report the toxicological and pharmacokinetic properties of the synthetic, small interfering RNA I5NP following intravenous administration in rodents and nonhuman primates. I5NP is designed to act via the RNA interference (RNAi) pathway to temporarily inhibit expression of the pro-apoptotic protei...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Thompson, James D., Kornbrust, Douglas J., Foy, Jeffrey W-D., Solano, Elisabeth C.R., Schneider, David J., Feinstein, Elena, Molitoris, Bruce A., Erlich, Shai
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2012
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426203/
https://ncbi.nlm.nih.gov/pubmed/22913596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2012.0371
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak