Toxicological and Pharmacokinetic Properties of Chemically Modified siRNAs Targeting p53 RNA Following Intravenous Administration

We report the toxicological and pharmacokinetic properties of the synthetic, small interfering RNA I5NP following intravenous administration in rodents and nonhuman primates. I5NP is designed to act via the RNA interference (RNAi) pathway to temporarily inhibit expression of the pro-apoptotic protei...

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Bibliografske podrobnosti
Main Authors: Thompson, James D., Kornbrust, Douglas J., Foy, Jeffrey W-D., Solano, Elisabeth C.R., Schneider, David J., Feinstein, Elena, Molitoris, Bruce A., Erlich, Shai
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426203/
https://ncbi.nlm.nih.gov/pubmed/22913596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2012.0371
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