siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this property to test the efficacy of siRNA targeted to p53, a pivotal protein in the apoptotic pathway,...

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Main Authors: Molitoris, Bruce A., Dagher, Pierre C., Sandoval, Ruben M., Campos, Silvia B., Ashush, Hagit, Fridman, Eduard, Brafman, Anat, Faerman, Alexander, Atkinson, Simon J., Thompson, James D., Kalinski, Hagar, Skaliter, Rami, Erlich, Shai, Feinstein, Elena
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2009
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723992/
https://ncbi.nlm.nih.gov/pubmed/19470675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008111204
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