Ocular neuroprotection by siRNA targeting caspase-2

Retinal ganglion cell (RGC) loss after optic nerve damage is a hallmark of certain human ophthalmic diseases including ischemic optic neuropathy (ION) and glaucoma. In a rat model of optic nerve transection, in which 80% of RGCs are eliminated within 14 days, caspase-2 was found to be expressed and...

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Detalhes bibliográficos
Main Authors: Ahmed, Z, Kalinski, H, Berry, M, Almasieh, M, Ashush, H, Slager, N, Brafman, A, Spivak, I, Prasad, N, Mett, I, Shalom, E, Alpert, E, Di Polo, A, Feinstein, E, Logan, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168996/
https://ncbi.nlm.nih.gov/pubmed/21677688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.54
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