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A rapid and convenient synthesis of poly-thymidylic acid by the modified triester approach.
By using anhydrous triethylamine-pyridine to selectively remove the cyanoethyl group from the fully protected oligonucleotide, a substantial improvement has been achieved in yields and the rates of condensation by the modified triester approach from the 5' leads to 3' end. The unreacted ol...
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| Gepubliceerd in: | Nucleic Acids Res |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
1977
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| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC342606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/909791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/4.8.2757 |
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