Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed), activated (open), and desensitized (closed) states....

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Autors principals: Shahsavar, Azadeh, Kastrup, Jette S., Nielsen, Elsebet Ø., Kristensen, Jesper L., Gajhede, Michael, Balle, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425559/
https://ncbi.nlm.nih.gov/pubmed/22927902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040757
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