Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

Insulin is secreted as discrete insulin secretory bursts at ∼5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated...

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Detalhes bibliográficos
Main Authors: Matveyenko, Aleksey V., Liuwantara, David, Gurlo, Tatyana, Kirakossian, David, Dalla Man, Chiara, Cobelli, Claudio, White, Morris F., Copps, Kyle D., Volpi, Elena, Fujita, Satoshi, Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425431/
https://ncbi.nlm.nih.gov/pubmed/22688333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1462
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