Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

Ultralow molecular weight (ULMW) heparins are sulfated glycans that are clinically used to treat thrombotic disorders. ULMW heparins range from 1500 to 3000 daltons, corresponding from 5 to 10 saccharide units. The commercial drug Arixtra (fondaparinux sodium) is a structurally homogeneous ULMW hepa...

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Main Authors: Xu, Yongmei, Masuko, Sayaka, Takieddin, Majde, Xu, Haoming, Liu, Renpeng, Jing, Juliana, Mousa, Shaker A., Linhardt, Robert J., Liu, Jian
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425363/
https://ncbi.nlm.nih.gov/pubmed/22034431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1207478
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