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The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

Werner’s syndrome (WS) and Bloom’s syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. In...

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Detalhes bibliográficos
Main Authors: Barefield, Colleen, Karlseder, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424559/
https://ncbi.nlm.nih.gov/pubmed/22576367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks407
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