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The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

Werner’s syndrome (WS) and Bloom’s syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. In...

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Main Authors: Barefield, Colleen, Karlseder, Jan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424559/
https://ncbi.nlm.nih.gov/pubmed/22576367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks407
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