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CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10
When mammalian cells experience radiation insult, DNA replication is stalled to prevent erroneous DNA synthesis. UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication. Here, we report that Mcm10 associates with E3 ubiquitin ligase com...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3424545/ https://ncbi.nlm.nih.gov/pubmed/22570418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks366 |
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