Ultraviolet Radiation Stress Triggers the Down-regulation of Essential Replication Factor Mcm10

We report that upon UV radiation insult, mammalian cells specifically down-regulate Mcm10, a protein essential for the initiation and elongation phases of DNA replication. The levels of a majority of replication factors remain unaffected under this condition, implying that Mcm10 is a key node in the...

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Bibliografiske detaljer
Main Authors: Sharma, Aparna, Kaur, Manpreet, Kar, Ananya, Ranade, Sourabh M., Saxena, Sandeep
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832985/
https://ncbi.nlm.nih.gov/pubmed/20064936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041129
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