CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

When mammalian cells experience radiation insult, DNA replication is stalled to prevent erroneous DNA synthesis. UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication. Here, we report that Mcm10 associates with E3 ubiquitin ligase com...

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Bibliographic Details
Main Authors: Kaur, Manpreet, Khan, Md. Muntaz, Kar, Ananya, Sharma, Aparna, Saxena, Sandeep
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424545/
https://ncbi.nlm.nih.gov/pubmed/22570418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks366
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