Intratumoral hu14.18–IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention

hu14.18–IL-2 (IC) is an immunocytokine consisting of human IL-2 linked to hu14.18 mAb, which recognizes the GD2 disialoganglioside. Phase 2 clinical trials of i.v. hu14.18–IL-2 (i.v.-IC) in neuroblastoma and melanoma are underway and have already demonstrated activity in neuroblastoma. We showed pre...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Yang, Richard K., Kalogriopoulos, Nicholas A., Rakhmilevich, Alexander L., Ranheim, Erik A., Seo, Songwon, Kim, KyungMann, Alderson, Kory L., Gan, Jacek, Reisfeld, Ralph A., Gillies, Stephen D., Hank, Jacquelyn A., Sondel, Paul M.
Format: Artigo
Jezik:Inglês
Izdano: AAI 2012
Teme:
Clinical Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424361/
https://ncbi.nlm.nih.gov/pubmed/22844125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200934
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki