AID-Initiated Off-Target DNA Breaks are Detected and Resolved During S-Phase

Activation-induced cytidine deaminase (AID) initiates DNA double strand breaks (DSBs) in the immunoglobulin heavy chain gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks in non-Igh (off-target) loci throughout the genome. Because the DSBs that initiate class swi...

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Autors principals: Hasham, Muneer G., Snow, Kathy J., Donghia, Nina M., Branca, Jane A., Lessard, Mark D., Stavnezer, Janet, Shopland, Lindsay S., Mills, Kevin D.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424338/
https://ncbi.nlm.nih.gov/pubmed/22826323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200414
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