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AID-Initiated Off-Target DNA Breaks are Detected and Resolved During S-Phase
Activation-induced cytidine deaminase (AID) initiates DNA double strand breaks (DSBs) in the immunoglobulin heavy chain gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks in non-Igh (off-target) loci throughout the genome. Because the DSBs that initiate class swi...
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| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3424338/ https://ncbi.nlm.nih.gov/pubmed/22826323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200414 |
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