Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth

Mechanical ventilation (MV) with O(2)-rich gas (MV-O(2)) offers life-saving treatment for newborn infants with respiratory failure, but it also can promote lung injury, which in neonates translates to defective alveolar formation and disordered lung elastin, a key determinant of lung growth and repa...

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Main Authors: Hilgendorff, Anne, Parai, Kakoli, Ertsey, Robert, Juliana Rey-Parra, G., Thébaud, Bernard, Tamosiuniene, Rasa, Jain, Noopur, Navarro, Edwin F., Starcher, Barry C., Nicolls, Mark R., Rabinovitch, Marlene, Bland, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423862/
https://ncbi.nlm.nih.gov/pubmed/22683569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00405.2011
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