Inhibiting Lung Elastase Activity Enables Lung Growth in Mechanically Ventilated Newborn Mice

Rationale: Mechanical ventilation with O(2)-rich gas (MV-O(2)) offers life-saving treatment for respiratory failure, but also promotes lung injury. We previously reported that MV-O(2) of newborn mice increased lung elastase activity, causing elastin degradation and redistribution of elastic fibers f...

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Hauptverfasser: Hilgendorff, Anne, Parai, Kakoli, Ertsey, Robert, Jain, Noopur, Navarro, Edwin F., Peterson, Joanna L., Tamosiuniene, Rasa, Nicolls, Mark R., Starcher, Barry C., Rabinovitch, Marlene, Bland, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175547/
https://ncbi.nlm.nih.gov/pubmed/21562133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201012-2010OC
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