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Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture

[Image: see text] Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to artifacts in screens for ligands of soluble proteins, the effects...

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Autori principali: Owen, Shawn C., Doak, Allison K., Wassam, Pascal, Shoichet, Molly S., Shoichet, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423826/
https://ncbi.nlm.nih.gov/pubmed/22625864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300189b
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