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Steric Restrictions of RISC in RNA Interference Identified with Size-Expanded RNA Nucleobases

Understanding the interactions between small interfering RNAs (siRNAs) and the RNA-induced silencing complex (RISC) – the key protein complex of RNA interference (RNAi) – is of great importance to the development of siRNAs with improved biological, and potentially therapeutic, function. Although var...

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Hlavní autoři: Hernández, Armando R., Peterson, Larryn W., Kool, Eric T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423588/
https://ncbi.nlm.nih.gov/pubmed/22646660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300174c
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