N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat

Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine (NOD) activates TRPV1 and if it improves AKI. T...

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Autors principals: Tsagogiorgas, Charalambos, Wedel, Johannes, Hottenrott, Maximilia, Schneider, Michael O., Binzen, Uta, Greffrath, Wolfgang, Treede, Rolf-Detlef, Theisinger, Bastian, Theisinger, Sonja, Waldherr, Rüdiger, Krämer, Bernhard K., Thiel, Manfred, Schnuelle, Peter, Yard, Benito A., Hoeger, Simone
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423369/
https://ncbi.nlm.nih.gov/pubmed/22916273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043525
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