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Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90

Heat shock protein 90 (Hsp90) is a significant target in the development of rational cancer therapy due to its role at the crossroads of multiple signaling pathways associated with cell proliferation and cell viability. The relevance of Hsp90 as a therapeutic target for numerous diseases states has...

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Hlavní autoři: Dal Piaz, Fabrizio, Vassallo, Antonio, Chini, Maria Giovanna, Cordero, Franca M., Cardona, Francesca, Pisano, Claudio, Bifulco, Giuseppe, De Tommasi, Nunziatina, Brandi, Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423353/
https://ncbi.nlm.nih.gov/pubmed/22916240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043316
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