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Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity
BACKGROUND: Hsp90 is an essential molecular chaperone that is also a novel anti-cancer drug target. There is growing interest in developing new drugs that modulate Hsp90 activity. METHODOLOGY/PRINCIPAL FINDINGS: Using a virtual screening approach, 4-hydroxytamoxifen, the active metabolite of the ant...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848575/ https://ncbi.nlm.nih.gov/pubmed/20376192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009934 |
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