Targeted Disruption of Heparan Sulfate Interaction with Hepatocyte and Vascular Endothelial Growth Factors Blocks Normal and Oncogenic Signaling

Hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) regulate normal development and homeostasis, and drive disease progression in many forms of cancer. Both proteins signal by binding to receptor tyrosine kinases and heparan sulfate (HS) proteoglycans on target cell sur...

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Autores principales: Cecchi, Fabiola, Pajalunga, Deborah, Fowler, C. Andrew, Uren, Aykut, Rabe, Daniel C., Peruzzi, Benedetta, MacDonald, Nicholas J., Blackman, Davida K., Stahl, Stephen J., Byrd, R. Andrew, Bottaro, Donald P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422512/
https://ncbi.nlm.nih.gov/pubmed/22897854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.06.029
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