A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted...

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Detalhes bibliográficos
Main Authors: Doria-Rose, Nicole A., Georgiev, Ivelin, O'Dell, Sijy, Chuang, Gwo-Yu, Staupe, Ryan P., McLellan, Jason S., Gorman, Jason, Pancera, Marie, Bonsignori, Mattia, Haynes, Barton F., Burton, Dennis R., Koff, Wayne C., Kwong, Peter D., Mascola, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421697/
https://ncbi.nlm.nih.gov/pubmed/22623764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00696-12
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