Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity and N-linked glycosylation. Human antibodies such as PG9 nonetheless enga...

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Auteurs principaux: McLellan, Jason S., Pancera, Marie, Carrico, Chris, Gorman, Jason, Julien, Jean-Philippe, Khayat, Reza, Louder, Robert, Pejchal, Robert, Sastry, Mallika, Dai, Kaifan, O’Dell, Sijy, Patel, Nikita, Shahzad-ul-Hussan, Syed, Yang, Yongping, Zhang, Baoshan, Zhou, Tongqing, Zhu, Jiang, Boyington, Jeffrey C., Chuang, Gwo-Yu, Diwanji, Devan, Georgiev, Ivelin, Kwon, Young Do, Lee, Doyung, Louder, Mark K., Moquin, Stephanie, Schmidt, Stephen D., Yang, Zhi-Yong, Bonsignori, Mattia, Crump, John A., Kapiga, Saidi H., Sam, Noel E., Haynes, Barton F., Burton, Dennis R., Koff, Wayne C., Walker, Laura M., Phogat, Sanjay, Wyatt, Richard, Orwenyo, Jared, Wang, Lai-Xi, Arthos, James, Bewley, Carole A., Mascola, John R., Nabel, Gary J., Schief, William R., Ward, Andrew B., Wilson, Ian A., Kwong, Peter D.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406929/
https://ncbi.nlm.nih.gov/pubmed/22113616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10696
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