An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p

Systemic life-threatening fungal infections represent a significant unmet medical need. Cell-based, phenotypic screening can be an effective means of discovering potential novel antifungal compounds, but it does not address target identification, normally required for compound optimization by medici...

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Hauptverfasser: Hoepfner, Dominic, Karkare, Shantanu, Helliwell, Stephen B., Pfeifer, Martin, Trunzer, Markus, De Bonnechose, Sophie, Zimmerlin, Alfred, Tao, Jianshi, Richie, Daryl, Hofmann, Andreas, Reinker, Stefan, Frederiksen, Mathias, Movva, N. Rao, Porter, Jeffrey A., Ryder, Neil S., Parker, Christian N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421618/
https://ncbi.nlm.nih.gov/pubmed/22615293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06332-11
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