Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

JTK-853 is a novel piperazine derivative nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase. JTK-853 showed potent inhibitory activity against genotype 1 HCV polymerase, with a 50% inhibitory concentration in the nanomolar range, and showed potent antiviral activity agai...

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Bibliografiske detaljer
Main Authors: Ando, Izuru, Adachi, Tsuyoshi, Ogura, Naoki, Toyonaga, Yukiyo, Sugimoto, Kazuyuki, Abe, Hiroyuki, Kamada, Masafumi, Noguchi, Toru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421577/
https://ncbi.nlm.nih.gov/pubmed/22615294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00312-12
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