Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

Tripartite motif protein TRIM5α blocks retroviral replication after cell entry, and species-specific differences in its activity are determined by sequence variations within the C-terminal B30.2/PRYSPRY domain. Here we report a high-resolution structure of a TRIM5α PRYSPRY domain, the PRYSPRY of the...

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Bibliographische Detailangaben
Hauptverfasser: Biris, Nikolaos, Yang, Yang, Taylor, Alexander B., Tomashevski, Andrei, Guo, Miao, Hart, P. John, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421187/
https://ncbi.nlm.nih.gov/pubmed/22847415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203536109
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