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Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) C...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ryan, Sean D., Britigan, Eric M. C., Zasadil, Lauren M., Witte, Kristen, Audhya, Anjon, Roopra, Avtar, Weaver, Beth A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421180/
https://ncbi.nlm.nih.gov/pubmed/22778409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201911109
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