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Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) C...

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Bibliografiske detaljer
Main Authors: Ryan, Sean D., Britigan, Eric M. C., Zasadil, Lauren M., Witte, Kristen, Audhya, Anjon, Roopra, Avtar, Weaver, Beth A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421180/
https://ncbi.nlm.nih.gov/pubmed/22778409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201911109
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