Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) C...

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Bibliographic Details
Main Authors: Ryan, Sean D., Britigan, Eric M. C., Zasadil, Lauren M., Witte, Kristen, Audhya, Anjon, Roopra, Avtar, Weaver, Beth A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421180/
https://ncbi.nlm.nih.gov/pubmed/22778409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201911109
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