CDK inhibitors up-regulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies

BH3 mimetic drugs induce cell death by antagonizing the activity of anti-apoptotic Bcl-2 family proteins. Cyclin-dependent kinase (CDK) inhibitors that function as transcriptional repressors down-regulate the Bcl-2 family member Mcl-1 and increase the activity of selective BH3-mimetics that fail to...

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Main Authors: Chen, Shuang, Dai, Yun, Pei, Xin-Yan, Myers, Jennifer, Wang, Li, Kramer, Lora B., Garnett, Mandy, Schwartz, Daniella M., Su, Florence, Simmons, Gary L., Richey, Justin D., Larsen, Dustin G., Dent, Paul, Orlowski, Robert Z., Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421040/
https://ncbi.nlm.nih.gov/pubmed/22693249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1118
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