Enhanced antitumoral efficacy and immune response following conditionally replicative adenovirus containing constitutive HSF1 delivery to rodent tumors

BACKGROUND: Oncolytic adenoviruses are promising as anticancer agents but have limited clinical responses. Our previous study showed that heat shock transcription factor 1 (HSF1) overexpression could increase the anti-tumor efficacy of E1B55kD deleted oncolytic adenovirus through increasing the vira...

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Hauptverfasser: Fan, Rong, Wang, Cheng, Wang, Yang, Ren, Ping, Gan, Pingping, Ji, Hui, Xia, Zian, Hu, Suiyu, Zeng, Qiongyao, Huang, Wei, Jiang, Yebin, Huang, Xi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419635/
https://ncbi.nlm.nih.gov/pubmed/22613625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-101
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