Synergistic antitumoral efficacy of a novel replicative adenovirus SG611-PDCD5 and daunorubicin in human leukemic cells

BACKGROUND: Daunorubicin is a traditional chemotherapeutic agent that plays a pivotal role in leukemia therapy. However, the dose-related toxicity remains a considerable challenge. The apoptosis-regulating gene, PDCD5, is downregulated in various tumors, including leukemias, and may provide a potent...

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Bibliographic Details
Published in:Onco Targets Ther
Main Authors: Zhou, Ya-Lan, Yao, Qiu-Mei, Zhou, Jiao, Chang, Yan, Li, Jin-Lan, Wang, Ya-Zhe, Wu, Hong-Ping, Chen, Yu-Hong, Liu, Yan-Rong, Huang, Xiao-Jun, Ruan, Guo-Rui
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112794/
https://ncbi.nlm.nih.gov/pubmed/30197523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S167868
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