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ENABLING CLINICAL CANCER GENOMICS FOR RARE MUTATIONS: COLD-PCR MAGNIFIES MUTATIONS PRIOR TO TARGETED AMPLICON RE-SEQUENCING

Despite widespread interest in the application of next-generation-sequencing (NGS) to the mutation profiling of individual cancer specimens, the onset of personalized clinical genomics is currently stalled due in part to technical hurdles. As tumors are genetically-heterogeneous and often mixed with...

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Main Authors: Milbury, Coren A., Correll, Mick, Quackenbush, John, Rubio, Renee, Makrigiorgos, G. Mike
格式: Artigo
語言:Inglês
出版: 2011
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418918/
https://ncbi.nlm.nih.gov/pubmed/22194627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2011.176198
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