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Enrichment of Mutations in Multiple DNA Sequences Using COLD-PCR in Emulsion

BACKGROUND: Multiplex detection of low-level mutant alleles in the presence of wild-type DNA would be useful for several fields of medicine including cancer, pre-natal diagnosis and infectious diseases. COLD-PCR is a recently developed method that enriches low-level mutations during PCR cycling, thu...

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Détails bibliographiques
Auteurs principaux: Castellanos-Rizaldos, Elena, Milbury, Coren Audrey, Makrigiorgos, G. Mike
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516544/
https://ncbi.nlm.nih.gov/pubmed/23236486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051362
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