Phosphate Groups of Lipid A Are Essential for Salmonella enterica Serovar Typhimurium Virulence and Affect Innate and Adaptive Immunity

Lipid A is a key component of the outer membrane of Gram-negative bacteria and stimulates proinflammatory responses via the Toll-like receptor 4 (TLR4)-MD2-CD14 pathway. Its endotoxic activity depends on the number and length of acyl chains and its phosphorylation state. In Salmonella enterica serov...

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Detalhes bibliográficos
Main Authors: Kong, Qingke, Six, David A., Liu, Qing, Gu, Lillian, Wang, Shifeng, Alamuri, Praveen, Raetz, Christian R. H., Curtiss, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418755/
https://ncbi.nlm.nih.gov/pubmed/22753374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00123-12
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