Regulated Delayed Expression of rfaH in an Attenuated Salmonella enterica Serovar Typhimurium Vaccine Enhances Immunogenicity of Outer Membrane Proteins and a Heterologous Antigen

RfaH is a transcriptional antiterminator that reduces the polarity of long operons encoding secreted and surface-associated cell components of Salmonella enterica serovar Typhimurium, including O antigen and lipopolysaccharide core sugars. A ΔrfaH mutant strain is attenuated in mice (50% lethal dose...

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Bibliographic Details
Main Authors: Kong, Qingke, Liu, Qing, Roland, Kenneth L., Curtiss, Roy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786485/
https://ncbi.nlm.nih.gov/pubmed/19805538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00831-09
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