Down-Regulation of Key Virulence Factors Makes the Salmonella enterica Serovar Typhimurium rfaH Mutant a Promising Live-Attenuated Vaccine Candidate

Mutants of Salmonella enterica serovar Typhimurium that lack the transcriptional regulator RfaH are efficient as live oral vaccines against salmonellosis in mice. We show that the attenuation of the vaccine candidate strain is associated with reduced net growth in epithelial and macrophage cells. In...

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Bibliographische Detailangaben
Hauptverfasser: Nagy, Gábor, Danino, Vittoria, Dobrindt, Ulrich, Pallen, Mark, Chaudhuri, Roy, Emödy, Levente, Hinton, Jay C., Hacker, Jörg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594928/
https://ncbi.nlm.nih.gov/pubmed/16988271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00619-06
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