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Down-Regulation of Key Virulence Factors Makes the Salmonella enterica Serovar Typhimurium rfaH Mutant a Promising Live-Attenuated Vaccine Candidate

Mutants of Salmonella enterica serovar Typhimurium that lack the transcriptional regulator RfaH are efficient as live oral vaccines against salmonellosis in mice. We show that the attenuation of the vaccine candidate strain is associated with reduced net growth in epithelial and macrophage cells. In...

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Autors principals: Nagy, Gábor, Danino, Vittoria, Dobrindt, Ulrich, Pallen, Mark, Chaudhuri, Roy, Emödy, Levente, Hinton, Jay C., Hacker, Jörg
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594928/
https://ncbi.nlm.nih.gov/pubmed/16988271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00619-06
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