Down-Regulation of Key Virulence Factors Makes the Salmonella enterica Serovar Typhimurium rfaH Mutant a Promising Live-Attenuated Vaccine Candidate

Mutants of Salmonella enterica serovar Typhimurium that lack the transcriptional regulator RfaH are efficient as live oral vaccines against salmonellosis in mice. We show that the attenuation of the vaccine candidate strain is associated with reduced net growth in epithelial and macrophage cells. In...

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Hlavní autoři: Nagy, Gábor, Danino, Vittoria, Dobrindt, Ulrich, Pallen, Mark, Chaudhuri, Roy, Emödy, Levente, Hinton, Jay C., Hacker, Jörg
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594928/
https://ncbi.nlm.nih.gov/pubmed/16988271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00619-06
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