Blockade of the MEK/ERK signaling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo

We investigate cytotoxicity and mechanism of action of AS703026, a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026, more potently (9-10 fold) than AZD6244, inhibited growth and survival of MM cells and cytokine-induced osteoclast differentiation. Inhi...

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Detalhes bibliográficos
Main Authors: Kim, Kihyun, Kong, Sun-Young, Fulciniti, Mariateresa, Li, Xianfeng, Song, Weihua, Nahar, Sabikun, Burger, Peter, Rumizen, Mathew J, Podar, Klaus, Chauhan, Dharminder, Hideshima, Teru, Munshi, Nikhil C., Richardson, Paul, Clark, Ann, Ogden, Janet, Goutopoulos, Andreas, Rastelli, Luca, Anderson, Kenneth C., Tai, Yu-Tzu
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418597/
https://ncbi.nlm.nih.gov/pubmed/20331454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08127.x
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