Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

Activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signaling cascade mediates human multiple myeloma (MM) growth and survival triggered by cytokines and adhesion to bone marrow stromal cells (BMSCs). Here, we examined the effect of AZD6244 (ARRY-142886), a novel and specific MEK1/2...

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Bibliografiske detaljer
Main Authors: Tai, Yu-Tzu, Fulciniti, Mariateresa, Hideshima, Teru, Song, Weihua, Leiba, Merav, Li, Xian-Feng, Rumizen, Matthew, Burger, Peter, Morrison, Aileen, Podar, Klaus, Chauhan, Dharminder, Tassone, Pierfrancesco, Richardson, Paul, Munshi, Nikhil C., Ghobrial, Irene M., Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975848/
https://ncbi.nlm.nih.gov/pubmed/17510321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-081240
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