Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

Decreased activity of osteoblasts (OBs) contributes to osteolytic lesions in multiple myeloma (MM). The production of the soluble Wnt inhibitor Dickkopf-1 (DKK1) by MM cells inhibits OB activity, and its serum level correlates with focal bone lesions in MM. Therefore, we have evaluated bone anabolic...

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Détails bibliographiques
Auteurs principaux: Fulciniti, Mariateresa, Tassone, Pierfrancesco, Hideshima, Teru, Vallet, Sonia, Nanjappa, Puru, Ettenberg, Seth A., Shen, Zhenxin, Patel, Nipun, Tai, Yu-tzu, Chauhan, Dharminder, Mitsiades, Constantine, Prabhala, Rao, Raje, Noopur, Anderson, Kenneth C., Stover, David R., Munshi, Nikhil C.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714212/
https://ncbi.nlm.nih.gov/pubmed/19417213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-191577
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