Significant biological role of Sp1 transactivation in multiple myeloma

PURPOSE: The transcription factor Sp1 controls number of cellular processes by regulating the expression of critical cell cycle, differentiation and apoptosis-related genes containing proximal GC/GT-rich promoter elements. We here provide both experimental and clinical evidence that Sp1 plays an imp...

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Pubblicato in:Clin Cancer Res
Autori principali: Fulciniti, Mariateresa, Amin, Samir, Nanjappa, Puru, Rodig, Scott, Prabhala, Rao, Li, Cheng, Minvielle, Stephane, Tai, Yu-tzu, Tassone, Pierfrancesco, Avet-Loiseau, Herve, Hideshima, Teru, Anderson, Kenneth C., Munshi, Nikhil C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318245/
https://ncbi.nlm.nih.gov/pubmed/21856768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1036
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