Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques

Previous studies demonstrated that the nef gene is a critical determinant of the pathogenicity of simian immunodeficiency virus (SIV) in macaques. In the present study, we evaluated the effect of a spontaneous frameshift mutation in the C-terminus of the nef gene of the minimally pathogenic SIVsmH4i...

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Hauptverfasser: Zheng, Yanfang, Ourmanov, Ilnour, Goeken, Robert M., Whitted, Sonya, Brown, Charles R., Buckler-White, Alicia, Iyengar, Ranjini, Plishka, Ronald J., Hirsch, Vanessa M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418331/
https://ncbi.nlm.nih.gov/pubmed/20303562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.02.026
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