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Hydrophilic Side Chains in the Third and Seventh Transmembrane Helical Domains of Human A(2A) Adenosine Receptors Are Required for Ligand Recognition
Hydrophilic residues of the G protein-coupled human A(2A) adenosine receptor that are potentially involved in the binding of the ribose moiety of adenosine were targeted for mutagenesis. Residues in a T(88)QSS(91) sequence in the third transmembrane helical domain (TM3) were individually replaced wi...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418326/ https://ncbi.nlm.nih.gov/pubmed/8794889 |
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