The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME

The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways in which PRAME is implicated are not well understood....

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Autori principali: Costessi, Adalberto, Mahrour, Nawel, Sharma, Vikram, Stunnenberg, Rieka, Stoel, Marieke A., Tijchon, Esther, Conaway, Joan W., Conaway, Ronald C., Stunnenberg, Hendrik G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418287/
https://ncbi.nlm.nih.gov/pubmed/22912744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042822
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